ABSTRACT
Background: Pharmacological studies suggest that sublingual route might be the optimal route of administration for PGE1 analogue misoprostol because the avoidance of the first pass hepatic circulation would yield bioavailability like that achieved with the vaginal route along with an earlier onset of action and a prolonged activity
Objective: The aim of this study was to compare the efficacy and the safety of vaginal misoprostol with sublingual misoprostol for induction of labor in post-term pregnancy
Subjects and Methods: This study included 50 cases, each with a singleton post-term pregnancy and a live fetus requiring induction of labor were allocated to sublingual and vaginal administration of misoprostol. Outcome measures related to labor and maternal and fetal side effects were compared between the 2 groups and evaluated using Chi square test
Results: The sublingual route of misoprostol was associated with a reduced risk of failed induction, reduced time from initiation to induction, reduced induction to delivery interval and a higher incidence of maternal and fetal side effects. However, the differences were not statistically significant
Conclusion: The sublingual route of administration of misoprostol is comparable in efficacy and safety to the vaginal route for induction
ABSTRACT
Background: in the last decade, the prevalence of obesity has significantly increased in populations worldwide and becomes epidemic. Obesity has been documented by World Health Organization [WHO] as "a pandemic nutritional disorder. Egypt had the highest average Body Mass Index [BMI] and obesity in the world
Aim of the Work: evaluation of the possible effects of increased body mass index on pregnancy and measure its maternal, fetal and neonatal outcomes
Patients and Methods: the present study was approved from alazhar research ethical committee. The present study was carried out in Obstetrics and gynecology out-patient, Nasr city police hospital and El-hussien university hospital. Three hundred [300] pregnant women were included in the study; they were divided into3 groups: Group I 150 pregnant women with normal weight [BMI = 18.5 - 24.9 kg/m2]. Group II: 75 pregnant women who are overweight [BMI = 25 - 29.9 kg/m2]. Group III: 75 pregnant women who are obese [BMI >/= 30 kg/m2]. Groups were subjected to full history taking, clinical examination, obstetric palpation, ultrasound, investigations, antenatal care, post natal care and neonatal assessment
Results: statistical significant relationship between increased BMI and incidence of gestational hypertension, diabetes, postpartum hemorrhage and macrosomia. No Statistical significant relationship was found between increased BMI and incidence of cesarean rate, wound infection and intra uterine fetal retardation [IUGR]
Conclusion: maternal obesity carries significant risks for the mother and fetus, including maternal outcomes as increased incidence of hypertension, gestational diabetes, cesarean rates, and postpartum hemorrhage. Fetal outcomes as macrosomia
ABSTRACT
Background: Unexplained Recurrent miscarriage remains a frustrating problem for the clinician and a distressing condition for the affected couple. Recurrent pregnancy loss is defined as three or more successive spontaneous abortion. The incidence of recurrent pregnancy loss is 1-2% in the fertile population
Aim of the Work: This study aimed to find out any difference in uterine artery pulsitility index [PI] between women with history of recurrent unexplained first trimestric abortion and women without this history
Patients and Methods: One hundred cases from Al-Azhar University Hospitals [Al-Hussein and Sayed Galal] were included in the study and classified into two groups: Recurrent pregnancy loss [RPL] group: 50 cases with history of recurrent unexplained abortion. Control group: 50 cases with no history of abortion and one full term child at least. Uterine artery Doppler [Pulsatility Index [PI]] assessment was done to all patients in the study during the luteal phase of spontaneous menstrual cycle
Results: PI in the RPL group was found to be elevated compared to the control group
Conclusion: Assessment of uterine perfusion through measurement of uterine artery Doppler [PI] could be of value in cases with recurrent unexplained first trimestric abortion
ABSTRACT
To compare pregnancy rate [PR] per patient and per treatment cycle of controlled ovarian hyperstimulation [COH] patients receiving a single intrauterine insemination [IUI] with COH receiving two IUIs. 27 patients underwent 124 COH by clomiphene citrate and were randomized to receive either single or two IUIs. Single IUI group were timed 34 hours after HCG whereas double IUIs were performed 12 and 34 hours after HCG intake. Clinical pregnancy developed in 3 out of 35 patients in the single IUI group treated for 58 cycles [PR per patient and cycle was 8.7%, 5.2% respectively] compared with 11 pregnancies out of 37 patients in the double IUIs group treated for 66 cycles [PR per patient and per cycle was 29.7%, 16.7% respectively]. There was a statistically significant difference between both groups. In COH cycles, two preovulatory IUIs provide an increase in cycle PR
Subject(s)
Humans , Female , Infertility , Follicular Phase , Ovulation Induction , Pregnancy RateABSTRACT
This study aimed to evaluate the predictive efficacy of two biochemical markers, the vaginal fetal fibronectin and maternal dehydroepiandrosterone sulfate for the fate of labor induction attempt. The reliability as well as the efficacy of their use together with Bishop score as selection criteria for induction of labor were also assessed. One hundred women with singleton pregnancies above 37 weeks gestation and with various indications for induction of labor with no signs of maternal of fetal compromise were enrolled in this study. After clinical assessment and fulfillment of selection criteria, patients were randomly allocated in two equal groups to have either vaginal fetal fibronectin [FFN] [GI=50] or maternal serum dehydroepiandrosterone sulfate [DHEAS] [GII=50] as a biochemical marker. Prior to induction of labor, all women were subjected to a detailed medical history, clinical examination including the cervical Bishop scoring, ultrasonographic assessment and estimation of the offered biochemical marker in each group. Induction-active phase interval was measured for all participants. The main outcome measures were mean concentrations of vaginal [FFN] and maternal [DHEAS], bishop score and induction-active phase interval. From this study, it was concluded that both fetal fibronectin and maternal dehydroepiandrosterone sulfate are effective predictors of the induction-active phase interval